Publications

Brindley, P. J., Bachini, M., Ilyas, S. I., Khan, S. A., Loukas, A., Sirica, A. E., Teh, B. T., Wongkham, S., & Gores, G. J. (2021). Cholangiocarcinoma. Nature reviews. Disease primers, 7(1), 65. https://doi.org/10.1038/s41572-021-00300-2

da Costa, J., Gouveia, M. J., Rinaldi, G., Brindley, P. J., Santos, J., & Santos, L. L. (2021). Control Strategies for Carcinogenic-Associated Helminthiases: An Integrated Overview. Frontiers in cellular and infection microbiology, 11, 626672. https://doi.org/10.3389/fcimb.2021.626672

Mairiang, E., Laha, T., Kaewkes, S., Loukas, A., Bethony, J., Brindley, P. J., & Sripa, B. (2021). Hepatobiliary morbidities detected by ultrasonography in Opisthorchis viverrini-infected patients before and after praziquantel treatment: a five-year follow up study. Acta tropica, 217, 105853. https://doi.org/10.1016/j.actatropica.2021.105853

Phuakrod, A., Sripumkhai, W., Jeamsaksiri, W., Pattamang, P., Loymek, S., Brindley, P. J., Sarasombath, P. T., & Wongkamchai, S. (2021). A miniPCR-Duplex Lateral Flow Dipstick Platform for Rapid and Visual Diagnosis of Lymphatic Filariae Infection. Diagnostics (Basel, Switzerland), 11(10), 1855. https://doi.org/10.3390/diagnostics11101855

Phumrattanaprapin, W., Chaiyadet, S., Brindley, P. J., Pearson, M., Smout, M. J., Loukas, A., & Laha, T. (2021). Orally Administered Bacillus Spores Expressing an Extracellular Vesicle-Derived Tetraspanin Protect Hamsters Against Challenge Infection With Carcinogenic Human Liver Fluke. The Journal of infectious diseases, 223(8), 1445–1455. https://doi.org/10.1093/infdis/jiaa516

Phumrattanaprapin, W., Pearson, M., Pickering, D., Tedla, B., Smout, M., Chaiyadet, S., Brindley, P. J., Loukas, A., & Laha, T. (2021). Monoclonal Antibodies Targeting an Opisthorchis viverrini Extracellular Vesicle Tetraspanin Protect Hamsters against Challenge Infection. Vaccines, 9(7), 740. https://doi.org/10.3390/vaccines9070740

Phupiewkham, W., Sadaow, L., Sanpool, O., Rodpai, R., Yamasaki, H., Ittiprasert, W., Mann, V. H., Brindley, P. J., Maleewong, W., & Intapan, P. M. (2021). Comparative assessment of immunochromatographic test kits using somatic antigens from adult Opisthorchis viverrini and IgG and IgG4 conjugates for serodiagnosis of human opisthorchiasis. Parasitology research, 120(8), 2839–2846. https://doi.org/10.1007/s00436-021-07224-6

Rodpai, R., Sanpool, O., Thanchomnang, T., Laoraksawong, P., Sadaow, L., Boonroumkaew, P., Wangwiwatsin, A., Wongkham, C., Laummaunwai, P., Ittiprasert, W., Brindley, P. J., Intapan, P. M., & Maleewong, W. (2021). Exposure to dexamethasone modifies transcriptomic responses of free-living stages of Strongyloides stercoralis. PloS one, 16(6), e0253701. https://doi.org/10.1371/journal.pone.0253701

Santos, L. L., Santos, J., Gouveia, M. J., Bernardo, C., Lopes, C., Rinaldi, G., Brindley, P. J., & Costa, J. (2021). Urogenital Schistosomiasis-History, Pathogenesis, and Bladder Cancer. Journal of clinical medicine, 10(2), 205. https://doi.org/10.3390/jcm10020205

Smith, M., Yadav, S., Fagunloye, O. G., Pels, N. A., Horton, D. A., Alsultan, N., Borns, A., Cousin, C., Dixon, F., Mann, V. H., Lee, C., Brindley, P. J., El-Sayed, N. M., Bridger, J. M., & Knight, M. (2021). PIWI silencing mechanism involving the retrotransposon nimbus orchestrates resistance to infection with Schistosoma mansoni in the snail vector, Biomphalaria glabrata. PLoS neglected tropical diseases, 15(9), e0009094. https://doi.org/10.1371/journal.pntd.0009094

Takaki, K. K., Roca, F. J., Schramm, G., Wilbers, R., Ittiprasert, W., Brindley, P. J., Rinaldi, G., Berriman, M., Ramakrishnan, L., & Pagán, A. J. (2021). Tumor Necrosis Factor and Schistosoma mansoni egg antigen omega-1 shape distinct aspects of the early egg-induced granulomatous response. PLoS neglected tropical diseases, 15(1), e0008814. https://doi.org/10.1371/journal.pntd.0008814

You, H., Mayer, J. U., Johnston, R. L., Sivakumaran, H., Ranasinghe, S., Rivera, V., Kondrashova, O., Koufariotis, L. T., Du, X., Driguez, P., French, J. D., Waddell, N., Duke, M. G., Ittiprasert, W., Mann, V. H., Brindley, P. J., Jones, M. K., & McManus, D. P. (2021). CRISPR/Cas9-mediated genome editing of Schistosoma mansoni acetylcholinesterase. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 35(1), e21205. https://doi.org/10.1096/fj.202001745RR

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Arunsan, P., Chaidee, A., Cochran, C. J., Mann, V. H., Tanno, T., Kumkhaek, C., Smout, M. J., Karinshak, S. E., Rodpai, R., Sotillo, J., Loukas, A., Laha, T., Brindley, P. J., & Ittiprasert, W. (2020). Liver fluke granulin promotes extracellular vesicle-mediated crosstalk and cellular microenvironment conducive to cholangiocarcinoma. Neoplasia (New York, N.Y.), 22(5), 203–216. https://doi.org/10.1016/j.neo.2020.02.004

Bernardo, C., Santos, J., Costa, C., Tavares, A., Amaro, T., Marques, I., Gouveia, M. J., Félix, V., Afreixo, V., Brindley, P. J., Costa, J. M., Amado, F., Helguero, L., & Santos, L. L. (2020). Estrogen receptors in urogenital schistosomiasis and bladder cancer: Estrogen receptor alpha-mediated cell proliferation. Urologic oncology, 38(9), 738.e23–738.e35. https://doi.org/10.1016/j.urolonc.2020.04.022

Choi, Y. J., Fontenla, S., Fischer, P. U., Le, T. H., Costábile, A., Blair, D., Brindley, P. J., Tort, J. F., Cabada, M. M., & Mitreva, M. (2020). Adaptive Radiation of the Flukes of the Family Fasciolidae Inferred from Genome-Wide Comparisons of Key Species. Molecular biology and evolution, 37(1), 84–99. https://doi.org/10.1093/molbev/msz204

Coelho, F. S., Rodpai, R., Miller, A., Karinshak, S. E., Mann, V. H., Dos Santos Carvalho, O., Caldeira, R. L., de Moraes Mourão, M., Brindley, P. J., & Ittiprasert, W. (2020). Diminished adherence of Biomphalaria glabrata embryonic cell line to sporocysts of Schistosoma mansoni following programmed knockout of the allograft inflammatory factor. Parasites & vectors, 13(1), 511. https://doi.org/10.1186/s13071-020-04384-9

Formenti, F., Cortés, A., Brindley, P. J., Cantacessi, C., & Rinaldi, G. (2020). A bug's life: Delving into the challenges of helminth microbiome studies. PLoS neglected tropical diseases, 14(9), e0008446. https://doi.org/10.1371/journal.pntd.0008446

Gouveia, M. J., Brindley, P. J., Gärtner, F., & Vale, N. (2020). Activity of Combinations of Antioxidants and Anthelmintic Drugs against the Adult Stage of Schistosoma mansoni. Journal of parasitology research, 2020, 8843808. https://doi.org/10.1155/2020/8843808

Hotez, P. J., Aksoy, S., Brindley, P. J., & Kamhawi, S. (2020). World neglected tropical diseases day. PLoS neglected tropical diseases, 14(1), e0007999. https://doi.org/10.1371/journal.pntd.0007999

Hotez, P. J., Aksoy, S., Brindley, P. J., & Kamhawi, S. (2020). What constitutes a neglected tropical disease?. PLoS neglected tropical diseases, 14(1), e0008001. https://doi.org/10.1371/journal.pntd.0008001

Hotez, P. J., Bottazzi, M. E., Singh, S. K., Brindley, P. J., & Kamhawi, S. (2020). Will COVID-19 become the next neglected tropical disease?. PLoS neglected tropical diseases, 14(4), e0008271. https://doi.org/10.1371/journal.pntd.0008271

Mbanefo, E. C., Agbo, C. T., Zhao, Y., Lamanna, O. K., Thai, K. H., Karinshak, S. E., Khan, M. A., Fu, C. L., Odegaard, J. I., Saltikova, I. V., Smout, M. J., Pennington, L. F., Nicolls, M. R., Jardetzky, T. S., Loukas, A., Brindley, P. J., Falcone, F. H., & Hsieh, M. H. (2020). IPSE, an abundant egg-secreted protein of the carcinogenic helminth Schistosoma haematobium, promotes proliferation of bladder cancer cells and angiogenesis. Infectious agents and cancer, 15, 63. https://doi.org/10.1186/s13027-020-00331-6

Nawaratna, S., McManus, D. P., Gasser, R. B., Brindley, P. J., Boyle, G. M., Rivera, V., Ranasinghe, S. L., Jones, M. K., You, H., & Gobert, G. N. (2020). Use of kinase inhibitors against schistosomes to improve and broaden praziquantel efficacy. Parasitology, 147(13), 1488–1498. https://doi.org/10.1017/S0031182020001250

Rosa, B. A., Choi, Y. J., McNulty, S. N., Jung, H., Martin, J., Agatsuma, T., Sugiyama, H., Le, T. H., Doanh, P. N., Maleewong, W., Blair, D., Brindley, P. J., Fischer, P. U., & Mitreva, M. (2020). Comparative genomics and transcriptomics of 4 Paragonimus species provide insights into lung fluke parasitism and pathogenesis. GigaScience, 9(7), giaa073. https://doi.org/10.1093/gigascience/giaa073

Skinner, D. E., Popratiloff, A., Alrefaei, Y. N., Mann, V. H., Rinaldi, G., & Brindley, P. J. (2020). Functional analysis of vasa/PL10-like genes in the ovary of Schistosoma mansoni. Molecular and biochemical parasitology, 236, 111259. https://doi.org/10.1016/j.molbiopara.2020.111259

Thanaphongdecha, P., Karinshak, S. E., Ittiprasert, W., Mann, V. H., Chamgramol, Y., Pairojkul, C., Fox, J. G., Suttiprapa, S., Sripa, B., & Brindley, P. J. (2020). Infection with Helicobacter pylori Induces Epithelial to Mesenchymal Transition in Human Cholangiocytes. Pathogens (Basel, Switzerland), 9(11), 971. https://doi.org/10.3390/pathogens9110971

Thi Phung, L., Chaiyadet, S., Hongsrichan, N., Sotillo, J., Dinh Thi Dieu, H., Quang Tran, C., Brindley, P. J., Loukas, A., & Laha, T. (2020). Partial protection with a chimeric tetraspanin-leucine aminopeptidase subunit vaccine against Opisthorchis viverrini infection in hamsters. Acta tropica, 204, 105355. https://doi.org/10.1016/j.actatropica.2020.105355

Vale, N., Gouveia, M. J., Gärtner, F., & Brindley, P. J. (2020). Oxysterols of helminth parasites and pathogenesis of foodborne hepatic trematodiasis caused by Opisthorchis and Fasciola species. Parasitology research, 119(5), 1443–1453. https://doi.org/10.1007/s00436-020-06640-4

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Ittiprasert W, Mann VM, Karinshak SE, Coghlan A, Rinaldi G, Sankaranarayanan G, Chaidee A, Tanno T, Kumkhaek C, Prangtaworn P, Mentink-Kane M, Cochran CJ, Driguez P, Holroyd N, Tracey A, Rodpai R, Everts B, Hokke CH, Hoffmann KF, Berriman M, Brindley PJ. (2019) Programmed genome editing of the omega-1 ribonuclease of the blood fluke, Schistosoma mansoni. eLife. 2019 Jan 15;8. pii: e41463. doi: 0.7554/eLife.41337

Arunsan P, Ittiprasert W, Cochran CJ, Mann VH, Chaiyadet S, Sripa B, Young ND, Smout MJ, Sotillo J, Loukas A, Brindley PJ, Laha T. (2019) Infection with CRISPR/Cas9-gene-edited liver flukes attenuates virulence of Opisthorchis viverrini infection-induced hepatobiliary disease. eLife. 2019 Jan 15;8. pii: e41337. doi:10.7554/eLife.41463

Jenkins TP, Brindley PJ, Gasser RB, Cantacessi C.(2019) Helminth Microbiomes - A Hidden Treasure Trove?Trends Parasitol.2019 Jan;35(1):13-22. doi:10.1016/j.pt.2018.10.007.

Gouveia, M. J., Brindley, P. J., Rinaldi, G., Gärtner, F., da Costa, J., & Vale, N. (2019). Infection with carcinogenic helminth parasites and its production of metabolites induces the formation of DNA-adducts. Infectious agents and cancer, 14, 41. https://doi.org/10.1186/s13027-019-0257-2

Saltykova, I. V., Ittiprasert, W., Nevskaya, K. V., Dorofeeva, Y. B., Kirillova, N. A., Kulikov, E. S., Ivanov, V. V., Mann, V. H., Pershina, A. G., & Brindley, P. J. (2019). Hemozoin From the Liver Fluke, Opisthorchis felineus, Modulates Dendritic Cell Responses in Bronchial Asthma Patients. Frontiers in veterinary science, 6, 332. https://doi.org/10.3389/fvets.2019.00332

Phung, L. T., Chaiyadet, S., Hongsrichan, N., Sotillo, J., Dieu, H., Tran, C. Q., Brindley, P. J., Loukas, A., & Laha, T. (2019). Recombinant Opisthorchis viverrini tetraspanin expressed in Pichia pastoris as a potential vaccine candidate for opisthorchiasis. Parasitology research, 118(12), 3419–3427. https://doi.org/10.1007/s00436-019-06488-3

Dheilly, N. M., Martínez Martínez, J., Rosario, K., Brindley, P. J., Fichorova, R. N., Kaye, J. Z., Kohl, K. D., Knoll, L. J., Lukeš, J., Perkins, S. L., Poulin, R., Schriml, L., & Thompson, L. R. (2019). Parasite microbiome project: Grand challenges. PLoS pathogens, 15(10), e1008028. https://doi.org/10.1371/journal.ppat.1008028

Stroehlein, A. J., Korhonen, P. K., Chong, T. M., Lim, Y. L., Chan, K. G., Webster, B., Rollinson, D., Brindley, P. J., Gasser, R. B., & Young, N. D. (2019). High-quality Schistosoma haematobium genome achieved by single-molecule and long-range sequencing. GigaScience, 8(9), giz108. https://doi.org/10.1093/gigascience/giz108

Sadaow, L., Sanpool, O., Rodpai, R., Yamasaki, H., Ittiprasert, W., Mann, V. H., Brindley, P. J., Maleewong, W., & Intapan, P. M. (2019). Development of an Immunochromatographic Point-of-Care Test for Serodiagnosis of Opisthorchiasis and Clonorchiasis. The American journal of tropical medicine and hygiene, 101(5), 1156–1160. https://doi.org/10.4269/ajtmh.19-0446

Chaidee, A., Onsurathum, S., Intuyod, K., Haonon, O., Pannangpetch, P., Pongchaiyakul, C., Pinlaor, P., Pairojkul, C., Welbat, J. U., Ittiprasert, W., Cochran, C. J., Mann, V. H., Brindley, P. J., & Pinlaor, S. (2019). Opisthorchis viverrini Infection Augments the Severity of Nonalcoholic Fatty Liver Disease in High-Fat/High-Fructose Diet-Fed Hamsters. The American journal of tropical medicine and hygiene, 101(5), 1161–1169. https://doi.org/10.4269/ajtmh.19-0442

Dheilly, N. M., Ewald, P. W., Brindley, P. J., Fichorova, R. N., & Thomas, F. (2019). Parasite-microbe-host interactions and cancer risk. PLoS pathogens, 15(8), e1007912. https://doi.org/10.1371/journal.ppat.1007912

Nacif-Pimenta, R., da Silva Orfanó, A., Mosley, I. A., Karinshak, S. E., Ishida, K., Mann, V. H., Coelho, P., da Costa, J., Hsieh, M. H., Brindley, P. J., & Rinaldi, G. (2019). Differential responses of epithelial cells from urinary and biliary tract to eggs of Schistosoma haematobium and S. mansoni. Scientific reports, 9(1), 10731.

Tyagi, R., Elfawal, M. A., Wildman, S. A., Helander, J., Bulman, C. A., Sakanari, J., Rosa, B. A., Brindley, P. J., Janetka, J. W., Aroian, R. V., & Mitreva, M. (2019). Identification of small molecule enzyme inhibitors as broad-spectrum anthelmintics. Scientific reports, 9(1), 9085. https://doi.org/10.1038/s41598-019-45548-7

Gouveia, M. J., Brindley, P. J., Azevedo, C., Gärtner, F., da Costa, J., & Vale, N. (2019). The antioxidants resveratrol and N-acetylcysteine enhance anthelmintic activity of praziquantel and artesunate against Schistosoma mansoni. Parasites & vectors, 12(1), 309. https://doi.org/10.1186/s13071-019-3566-9

Chaiyadet, S., Sotillo, J., Krueajampa, W., Thongsen, S., Brindley, P. J., Sripa, B., Loukas, A., & Laha, T. (2019). Vaccination of hamsters with Opisthorchis viverrini extracellular vesicles and vesicle-derived recombinant tetraspanins induces antibodies that block vesicle uptake by cholangiocytes and reduce parasite burden after challenge infection. PLoS neglected tropical diseases, 13(5), e0007450. https://doi.org/10.1371/journal.pntd.0007450

Phuakrod, A., Sripumkhai, W., Jeamsaksiri, W., Pattamang, P., Juntasaro, E., Thienthong, T., Foongladda, S., Brindley, P. J., & Wongkamchai, S. (2019). Diagnosis of feline filariasis assisted by a novel semi-automated microfluidic device in combination with high resolution melting real-time PCR. Parasites & vectors, 12(1), 159. https://doi.org/10.1186/s13071-019-3421-z

Gouveia, M. J., Brindley, P. J., Rinaldi, G., Gärtner, F., Correia da Costa, J. M., & Vale, N. (2019). Combination Anthelmintic/Antioxidant Activity Against Schistosoma Mansoni. Biomolecules, 9(2), 54. https://doi.org/10.3390/biom9020054

Arunsan, P., Ittiprasert, W., Smout, M. J., Cochran, C. J., Mann, V. H., Chaiyadet, S., Karinshak, S. E., Sripa, B., Young, N. D., Sotillo, J., Loukas, A., Brindley, P. J., & Laha, T. (2019). Programmed knockout mutation of liver fluke granulin attenuates virulence of infection-induced hepatobiliary morbidity. eLife, 8, e41463. https://doi.org/10.7554/eLife.41463

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Saltykova IV, Petrov V, Brindley PJ. (2018) Opisthorchiasis and the microbiome. In Asiatic Liver Fluke - From Basic Science to Public Health. Advances in Parasitology 102, 1-23, https://www.sciencedirect.com/science/article/abs/pii/S0065308X18300526?via%3Dihub

Laha T, Brindley PJ, Suyapoh W, Suttiprapa S. (2018) RNA inference based genetic manipulation of Opisthorchis viverrini. In Asiatic Liver Fluke - From Basic Science to Public Health. Advances in Parasitology 102, 25-43, https://www.sciencedirect.com/science/article/abs/pii/S0065308X18300496?via%3Dihub

Sripa, B., Tangkawattana, S., Brindley, P.J. (2018). Update on pathogenesis of opisthorchiasis and cholangiocarcinoma In Asiatic Liver Fluke - From Basic Science to Public Health. Advances in Parasitology 102, 97-113, https://www.sciencedirect.com/science/article/abs/pii/S0065308X18300605?via%3Dihub

Chaidee A, Onsurathum S, Intuyod K, Pannangpetch P, Pongchaiyakul C, Pinlaor P, Pairojkul C, Ittiprasert W, Cochran CJ, Mann VH, Brindley PJ, Pinlaor S. (2018) PLoS Neglected Tropical Diseases 12(6):e0006611 https://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0006611

Upontain S, Sereerak P, Laha T, Sripa B, Tangkawatana P, Brindley PJ, Tangkawattana S. (2018) Granulin expression in hamsters during Opisthorchis viverrini infection-induced cholangiocarcinogenesis. Asian Pacific Journal of Cancer Prevention 19, 2437-2445, https://www.ncbi.nlm.nih.gov/pubmed/30255697https://pubs.acs.org/doi/10.1021/acsinfecdis.8b00090

Knight M, Brindley PJ, Bridger J. (2018) The snail, Biomphalaria glabrata, as a model to interrogate the molecular basis of complex human diseases. PLOS Neglected Tropical Diseases 12(8):e0006552 https://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0006552

Jenkins TP, Peachey LE, Ajami NJ, MacDonald AS, Hsieh MH, Brindley PJ, Cantacessi C, Rinaldi G. (2018) Schistosoma mansoni infection is associated with quantitative and qualitative modifications of the mammalian intestinal microbiota. Scientific Reports 8:12072,https://www.nature.com/articles/s41598-018-30412-x

Dastpeyman M, Bansal PS, Wilson D, Sotillo J, Brindley PJ, Loukas A, Smout MJ, Daly NL (2018) Structural variants of a liver fluke derived granulin peptide potently stimulate wound healing. Journal of Medicinal Chemistry 61, 8746-8753. https://pubs.acs.org/doi/10.1021/acs.jmedchem.8b00898

Yan HB, Smout MJ, Ju C, Folley AE, Skinner DE, Mann VH, Loukas A, Hu W, Brindley PJ, Rinaldi G. (2018) Developmental sensitivity in Schistosoma mansoni to puromycin to establish drug selection of transgenic schistosomes (2018) Antimicrobial Agents and Chemotherapy 62(8). pii: e02568-17, https://aac.asm.org/content/62/8/e02568-17

Tyagi R, Maddirala A, Alfawal M, Bidlow C, Bulman CA Rosa BA, Gao X, Chugani R, Zhou M, Helander J, Brindley PJ, Tseung C-C, Greig I, Sakanari J, Wildman SA, Aroian R, Janetka J, Mitreva M. (2018) Small molecule inhibitors of metabolic enzymes repurposed as a new class of anthelmintics. ACS Infectious Diseases 4(7),1130-1145 https://pubs.acs.org/doi/10.1021/acsinfecdis.8b00090

Stroehlein AJ, Young ND, Korhonen PK, Hall RS, Jex AR, Webster BL, Rollinson D, Brindley PJ, Gasser RB. (2018) The small RNA complement of adult Schistosoma haematobium. PLoS Neglected Tropical Diseases 12(5), e0006535 https://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0006535

Haugen B, Karinshak SE, Mann VH, Popratiloff A, Loukas A, Brindley PJ. Smout MJ* (2018) Granulin secreted by the food-borne liver fluke Opisthorchis viverrini promotes angiogenesis in human endothelial cells. Frontiers in Medicine 5:30. doi: 10.3389/fmed.2018.00030. https://www.frontiersin.org/articles/10.3389/fmed.2018.00030/full

Gouveia MJ, Brindley PJ, Gartner F, Correia da Costa JM, Vale N. (2018) Drug repurposing for schistosomiasis: combinations of drugs or biomolecules. Pharmaceuticals 11(1) pii: E15 doi: 10.3390/ph11010015 http://www.mdpi.com/1424-8247/11/1/15

Maggioli G, Rinaldi G, Giaudrone I, Beresain P, Tort JF Brindley PJ, Carmona C (2018) Expression, purification and characterization of two leucine amininopeptidases of the blood fluke Schistosoma mansoni. Molecular & Biochemical Parasiology 219, 17-23 http://www.sciencedirect.com/science/article/pii/S0166685117301512?via%3Dihub

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Suttiprapa S, Rinaldi G, Tsai IJ, Mann VH, Dubrovsky L, Yan HB, Holroyd N, Huckvale T, Durrant C, Protasio AV, Pushkarsky T, Iordanskiy S, Berriman M, Bukrinsky MI, Brindley PJ. (2016) HIV-1 Integrates Widely throughout the Genome of the Human Blood Fluke Schistosoma mansoni. PLoS Pathogens; 12(10):e1005931. http://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1005931

Saltykova IV, Petrov VA, Logacheva MD, Ivanova PG, Merzlikin NV, Sazonov AE, Ogorodova L, Brindley PJ. (2016) Biliary microbiota, gallstone disease and infection with Opisthorchis felineus. PLoS Neglected Tropical Diseases, 10(7):e0004809. https://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0004809

Knight M, Ittiprasert W, Arican-Goktas HD, Bridger JM (2016) Epigenetic modulation, stress and plasticity in susceptibility of the snail host, Biomphalaria glabrata to Schistosoma mansoni infection. International Journal for Parasitology, 46(7):389-94.

Saltykova IV, Ogorodova LM, Ivanov VV, Bogdanov AO, Gereng EA, Perina EA, Brindley PJ, Sazonov AE (2016) Carbonyl stress phenomena during chronic infection with Opisthorchis felineus. Parasitology International, in press. http://www.ncbi.nlm.nih.gov/pubmed/26773869

Bernardo C, Cunha MC, Santos JH, da Costa JM, Brindley PJ, Lopes C, Amado F, Ferreira R, Vitorino R, Santos LL (2016) Insight into the molecular basis of Schistosoma haematobium-induced bladder cancer through urine proteomics. Tumor Biology, in press. http://link.springer.com/article/10.1007%2Fs13277-016-4997-y

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Brindley PJ, Costa JM, Sripa B. (2015) Why does infection with some helminths cause cancer? Trends in Cancer, in press. http://www.cell.com/trends/cancer/abstract/S2405-8033(15)00034-5

Smout MJ, Sotillo J, Laha T, Papatpremsiri A, Rinaldi G, Pimenta RN, Chan LY, Johnson MS, Turnbull L, Whitchurch CB, Giacomin PR, Moran CS, Golledge J, Daly N, Sripa B, Mulvenna JP, Brindley PJ, Loukas A. (2015) Carcinogenic parasite secretes growth factor that accelerates wound healing and potentially promotes neoplasia. PLoS Pathogens 20;11(10):e1005209. http://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1005209

Pakharukova MY, Vavilin VA, Duzhak TG, Sripa B, Laha T, Brindley PJ, Mordvinov VA.(2015) Functional analysis of the unique cytochrome P450 of the liver fluke Opisthorchis felineus. PLoS Neglected Tropical Diseases 9(12):e0004258. http://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0004258 

Knight M, Elhelu O, Smith M, Haugen B, Miller A, Raghavan N, Wellman C, Cousin C, Dixon F, Mann V, Rinaldi G, Ittiprasert W, Brindley PJ. (2015) Susceptibility of snails to infection with schistosomes is influenced by temperature and expression of heat shock proteins. Epidemiology (Sunnyvale). 2015 5(2). pii: 189. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4618387/

Rinaldi G, Loukas A, Brindley PJ, Irelan J, Smout MJ. (2015) Viability of developmental stages of Schistosoma mansoni quantified with xCELLigence worm real-time motility assay (xWORM)International Journal for Parasitology: Drugs and Drug Resistance 5, 141-148             https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4534758/

Matchimakul P, Rinaldi G, Suttiprapa S, Mann VH, Popratiloff A, Pimenta, RN, Laha T, Cochran CJ, Kaewkes S, Sripa B, Brindley PJ (2015) Apoptosis of cholangiocytes modulated by thioredoxin of carcinogenic liver fluke. International Journal of Biochemistry & Cell Biology 65, 72-80 http://www.ncbi.nlm.nih.gov/pubmed/26007234

Wang JP, Shu-Qi Wang S-Q, Liu X-F, Xu B, Chai R-Y, Zhou P, Ju C, Sun J, Brindley PJ, Hu W. (2015) Intake of erythrocytes required for reproductive development of female Schistosoma japonicum. PLoS ONE 10(5):e0126822 http://www.plosone.org/article/fetchObject.action?uri=info:doi/10.1371/journal.pone.0126822&representation=PDF

Jurberg AD, Brindley PJ. (2015) Gene function in schistosomes: recent advances towards a cure. Editorial. Frontiers of Genetics 6:144 http://journal.frontiersin.org/article/10.3389/fgene.2015.00144/full

Rinaldi G, Yan H, Nacif-Pimenta R, Matchimakul P Bridger JM, Mann VH, Smout MJ, Brindley PJ, Knight M. (2015) Cytometric analysis, genetic manipulation and antibiotic selection of the snail embryonic cell line Bge from Biomphalaria glabrata, the intermediate host of Schistosoma mansoni. International Journal for Parasitology, International Journal for Parasitology 48, 527-535 http://www.ncbi.nlm.nih.gov/pubmed/25907768

Deenonpoe R, Chomvarin C, Pairojkul C, Chamgramol Y, Loukas A, Brindley PJ, Sripa B. (2015) The carcinogenic liver fluke Opisthorchis viverrini is a reservoir for species of Helicobacter. Asian Pacific Journal of Cancer Prevention 16, 1751-1758

http://www.apocpcontrol.org/paper_file/issue_abs/Volume16_No5/1751-1758%201.6%20Raksawan%20Deenonpoe.pdf

Gouveia MJ, Santos J, Brindley PJ, Rinaldi G, Lopes C, Santos LL, Vale N, Correia da Costa JM (2015) Estrogen-like metabolites and DNA-adducts in urogenital schistosomiasis-associated bladder cancer. Cancer Letters, 359, 226-232

http://www.cancerletters.info/article/S0304-3835(15)00040-3/abstract

Martin M, Rosa BA, Ozersky P, Wang Q, Hallsworth-Pepin K, Zhang X, Bhonagiri-Palsikar V, Tyagi R, Choi Y-J, Gao X, McNulty S, Brindley PJ, Mitreva M. (2015) Helminth.net: expansions to Nematode.net and an introduction to Trematode.net. Nucleic Acids Research 43, D698-706

http://nar.oxfordjournals.org/content/early/2014/11/11/nar.gku1128.full.pdf+ml

Ogorodova LM, Fedorova OS, Sripa B, Mordvinov VA, Katokhin AV, Keiser J, Odermatt P, Brindley PJ, Mayboroda OA, Velavan TP, Freidin MV, Sazonov AE, Saltykova IV, Pakharukova MY, Kovshirina V, Kaloulis K, Krylova O, Yazdanbakhsh M, and the TOPIC Consortium  (2015) Opisthorchiasis. Overlooked danger. PLoS Neglected Tropical Diseases 9(4): e0003563. doi:10.1371/journal.pntd.0003563  http://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0003563

Papatpremsiri A, Smout MJ, Loukas A, Brindley PJ, Sripa B, Laha T. (2015) Suppression of Ov-grn-1 encoding granulin of Opisthorchis viverrini inhibits proliferation of biliary epithelial cells. Experimental Parasitology 148, 17-23

http://www.sciencedirect.com/science/article/pii/S0014489414002471

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Correia da Costa JM, Vale N, Gouveia MJ, Botelho M, Sripa B, Santos LL, Santos J, Rinaldi

G, Brindley PJ (2014) Schistosome and liver fluke derived catechol-estrogens and helminth associated cancers. Frontiers in Genetics 5:444

http://journal.frontiersin.org/Journal/10.3389/fgene.2014.00444/full

Knight M, Arican-Goktas HD, Ittiprasert W, Odoemelam EC, Miller AN, Bridger JM (2014) Schistosomes and snails: a molecular encounter. Frontiers in Genetics 5:230

http://journal.frontiersin.org/article/10.3389/fgene.2014.00230/full

Hoffmann KF, Brindley PJ, Berriman M. (2014) Halting harmful helminths. Science, 346,

168-169, http://www.sciencemag.org/content/346/6206/168.full

Dell’oca N, Basika T, Corvo I, Castillo E, Brindley PJ, Rinaldi G, Tort JF. (2014) RNAi optimization in Fasciola hepatica newly excysted juveniles: long dsRNA induces more persistent silencing than siRNA. Molecular & Biochemical Parasitology 197, 28-35

http://www.sciencedirect.com/science/article/pii/S0166685114001406

Santos J, Fernandes E, Ferreira JA, Lima L, Tavares A, Parreira BS, Correia da Costa JM, Brindley PJ, Lopes C, Santos LL. (2014) P53 and cancer-associated sialylated glycans are surrogate markers of cancerization of the bladder associated with Schistosoma haematobium infection.  PLoS Neglected Tropical Diseases 8(12): e3329 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4263606/

Papatpremsiri A, Junpue P, Loukas A, Brindley PJ, Bethony JM, Sripa B, Laha T. (2014)

Immunization and challenge shown by hamsters infected with Opisthorchis viverrini

following exposure to gamma-irradiated metacercariae of this carcinogenic liver fluke.

Journal of Helminthology, 15, 1-9 http://journals.cambridge.org/action/displayAbstract?fromPage=online&aid=9384269&fileId=S0022149X14000741

Arican-Goktas HD, Ittiprasert W, Bridger JM, Knight M (2014) Differential spatial

repositioning of activated genes in Biomphalaria glabrata snails infected with

Schistosoma mansoni. PLoS Neglected Tropical Diseases 8(9): e3013,

http://www.plosntds.org/article/info%3Adoi%2F10.1371%2Fjournal.pntd.0003013

Rinaldi G, Honeycutt J, Young ND, Gasser RB, Brindley PJ, Hsieh MH. (2014) New research tools for urogenital schistosomiasis. Journal of Infectious Diseases, in press.

Plieskatt JL^*, Rinaldi G^*, Feng Y, Peng J, Yonglitthipagon P, Easley S, Laha T, Pairojkul C, Bhudhisawasdi V, Sripa B, Brindley PJ, Mulvenna JP, Bethony JM. (2014) Distinct miRNA signatures associate with subtypes of cholangiocarcinoma from infection with the tumorigenic liver fluke Opisthorchis viverrini. Journal of Hepatology, 61, 850-858 (^*Equal contribution.)

Mann VH, Suttiprapa S, Skinner DE, Brindley PJ, Rinaldi G (2014) Pseudotyped murine leukemia virus for schistosome transgenesis: approaches, methods and perspectives. Transgenic Research 23, 539-556

Zeraik AE, Galkin VE, Rinaldi, G, Garratt RC, Smout MJ, Loukas A, Mann VH, Araujo AP, DeMarco R, Brindley PJ (2014) Reversible paralysis of Schistosoma mansoni by forchlorfenuron, a phenylurea cytokinin that affects septins. International Journal for Parasitology 44, 523-531

Thanasuwan S, Piratae S, Brindley PJ, Loukas A, Kaewkes S, Laha T. (2014) Suppression ofaquaporin, a mediator of water channel control in the carcinogenic liver fluke, Opisthorchisviverrini. Parasites & Vectors 7:22 http://www.parasitesandvectors.com/content/pdf/1756-3305-7-224.pdf

Santos J, Gouveia MJ, Vale N, de Lurdes Delgado M, Gonçalves A, Teixeira da Silva JM, Oliveira C, Xavier P, Gomes P, Santos LL, Lopes C, Barros A, Rinaldi G, Brindley PJ, Correia da Costa JM, Sousa M, Botelho MC (2014) Urinary estrogen metabolites and self-reported infertility inwomen infected with Schistosoma haematobium. PLoS One, 9(5): e96774 http://www.plosone.org/article/fetchObject.action?uri=info%3Adoi%2F10.1371%2Fjournal.pone.0096774&representation=PDF

Plieskatt J, Rinaldi G, Brindley PJ, Jia X, Potriquet J, Bethony J, Mulvenna J. (2014) BioClojure:A functional library for the manipulation of biological sequences. Bioinformatics, http://bioinformatics.oxfordjournals.org/content/early/2014/05/02/bioinformatics.btu311.long

Yan H-B, Lou ZZ, Li L, Zheng Y, Brindley PJ, Luo X, Hou H, Guo A, Jia W-Z, Cai X-P. (2014)Genome-wide analysis of regulatory proteases sequences identified through bioinformatics data mining in Taenia solium. BMC Genomics 15(1):428 http://www.biomedcentral.com/content/pdf/1471-2164-15-428.pdf

Skinner DE, Rinaldi G, Koziol U, Brehm K, Brindley PJ (2014) How might flukes and tapeworms maintain genome integrity without a canonical piRNA pathway? Trends in Parasitology 30 (3), 123-129

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Zeraik AE, Rinaldi G, Mann VH, Popratiloff A, Araujo APU, DeMarco R, Brindley PJ (2013) Septins of platyhelminths: identification, phylogeny, expression and localization amongdevelopmental stages of Schistosoma mansoni. PLoS Neglected Tropical Diseases 7(12):e2602.

Plieskatt JL, Deenonpoe R, Mulvenna JP, Krause L, Sripa B, Bethony JM, Brindley PJ (2013) Infection with carcinogenic liver fluke Opisthorchis viverrini modifies intestinal and biliary microbiome. FASEB Journal 27, 4572-4584

Vale N, Gouveia MJ, Botelho M, Sripa B, Suttiprapa S, Rinaldi G, Gomes P, Brindley PJ, Correia da Costa JM (2013) Carcinogenic liver fluke Opisthorchis viverrini oxysterols detected by LC-MS/MS survey of soluble fraction parasite extract. Parasitology International, 62, 535-542

Botelho MC, Vale N, Gouveia MJ, Rinaldi G, Santos J, Santos LL, Gomes P, Brindley PJ, Costa JM (2013) Tumour-like phenotypes in urothelial cells after exposure to antigens from eggs of Schistosoma haematobium: An oestrogen–DNA adducts mediated pathway? International Journal for Parasitology 43, 17-26

Brindley PJ, Hotez PJ. (2013) Break out: Urogenital schistosomiasis and Schistosoma haematobium infection in the post-genomic era.  PLOS Neglected Tropical Diseases 7(3): e1961. PMC 3610632

Ittiprasert W, Miller A, Su X, Mu J, Bhusudsawang G, Ukoskit K, Knight M (2013) Identification and characterization of functional eSSR markers for genetic linkage mapping of Schistosoma mansoni juvenile resistance and susceptibility loci in Biomphalaria glabrata Int. J. Parasitol 43, 669-77

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Rinaldi G, Eckert SE, Tsai IJ, Suttiprapa S, Kines KJ, Tort JF, Mann VH, Turner DJ, Berriman M, Brindley PJ (2012) Germline transgenesis and insertional mutagenesis in Schistosoma mansoni mediated by Murine Leukemia Virus.  PLoS Pathogens 8(7): e1002820. PMC 3406096http://www.plospathogens.org/article/info%3Adoi%2F10.1371%2Fjournal.ppat.1002820

Sripa B, Brindley PJ, Mulvenna J, Laha T, Smout MJ, Mairiang E, Bethony JM, Loukas A  (2012) The tumorigenic liver fluke Opisthorchis viverrini – multiple pathways to cancer. Trends in Parasitology 28, 395-407.

Young ND, Jex AR, Li B, Liu S, Yang L, Xiong Z, Li L, Cantacessi C, Hall RS, Xu X, Chen F, Wu X, Zerlotini A, Oliveira G, Hofmann A, Zhang G, Fang X, Kang Y, Campbell BE, Loukas A, Ranganathan S, Rollinson D, Rinaldi G, Brindley PJ, Yang H, Wang Y, Wang J, Gasser RB (2012) Whole-genome sequence of Schistosoma haematobium.  Nature Genetics, 44(2), 221-215

Rinaldi G, Suttiprapa S, Tort JF, Folley AE, Skinner DE, Brinldey PJ (2012) An antibiotic selection marker for schistosome transgenesis. International Journal for Parasitology 42, 123-130

Skinner DE, Rinaldi G, Suttiprapa S, Mann VH, Smircich P, Cogswell AA, Williams DL, Brindley PJ (2012) Vasa–like DEAD-box RNA Helicases of Schistosoma mansoni.  PLoS Neglected Tropical Diseases, 6(6): e1686. doi:10.1371/journal.pntd.0001686

Ittiprasert W, Knight M (2012) Reversing the Resistance Phenotype of the Biomphalaria glabrata Snail Host Schistosoma mansoni Infection by Temperature Modulation. PLoS Pathogens 8(4): e1002677 (Evaluated in Faculty 1000)

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Rinaldi G, Popratiloff A, Okatcha TI, Ayuk MA, Suttiprapa S, Mann VH, Loukas A, Brindley PJ. (2011) Genetic manipulation of Schistosoma haematobium, the neglected schistosome. PLoS Neglected Tropical Diseases, 5(10): e1348. PMC 3191139

Suttiprapa S*, Rinaldi G*, Brindley PJ (2011) Prototypic chromatin insulator cHS4 protects retroviral transgene from silencing in Schistosoma mansoni. Transgenic Research 21, 555–566 (* These authors contributed equally to this work)

Sripa B, Bethony JM, Sithithaworn P., Kaewkes S., Mairiang E., Loukas A., Mulvenna J., Laha T., Hotez PJ., Brindley PJ. (2011) Opisthorchiasis and Opisthorchis-associated cholangiocarcinoma in Thailand and Laos. Acta Tropica 120 Suppl 1:S158-68  PMC3010517

Mann VH*, Suttiprapa S*, Rinaldi G*, Brindley PJ (2011) Establishing transgenic schistosomes. PLoS Neglected Tropical Diseases. Laboratory Symposium 5(8): e1230 (* These authors contributed equally to this work)

Knight, M., Miller, A., Liu, Y., Puthupparampil, S., Woodle, M., Ittiprasert, W. (2011) Polyethyleneimine (PEI) mediated siRNA gene silencing in the Schistosoma mansoni snail host, Biomphalaria glabrata. PLoS Neglected Tropical Diseases 5 (7):e1212. Evaluated in Faculty of 1000

Knight, M., Ittiprasert, W., Odoemelam, E., Adema, M.A., Miller A., Raghavan, N., Bridger, J. (2011) Non-random organization of the Biomphalaria glabrata genome in interphase Bge cellsl and the spatial repositioning of activated genes in cell co-cultured with Schistosoma mansoni.  International Journal for Parasitology 41, 61-70. Evaluated in Faculty of 1000 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3081665/

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Gilbert C, Schaak S, Pace II JK, Brindley PJ, Feschotte C. (2010) A role for host-parasite interactions in the horizontal transfer of transposons across phyla. Nature 464, 1347-1350. PMC3004128

Mann VH, Morales ME, Rinaldi G, Brindley PJ (2010) Culture for genetic manipulation of developmental stages of Schistosoma mansoni. Parasitology 137, 451-462. PMC 3042131

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Smout MJ, Laha T, Mulvenna J, Sripa B, Suttiprapa S, Jones A, Brindley PJ, Loukas A. (2009) A  granulin-like growth factor secreted by the carcinogenic liver fluke, Opisthorchis viverrini, promotes proliferation of host cells.  PLoS Pathogens 5(10):e1000611. PMC2749447

Schistosoma japonicum Genome Sequencing and Functional Analysis Consortium, Liu, F., Zhou, Y., Wang, ZQ., Lu, G., Zheng, H., Brindley PJ, McManus, D.P., Blair, D., Zhang, QH., Zhong, Y., Wang, S., Han, ZG., Chen, Z. (2009) The Schistosoma japonicum genome reveals features of host-parasite interplay. Nature 460, 345-352

Hotez PJ, Brindley PJ, Bethony JM, Pearce EJ, King CH, Jacobsen J. (2008) Helminth infections: the great neglected tropical diseases. Journal of Clinical Investigation 118, 1,311-1,321. PMC2276811

Rinaldi G, Morales ME,  Alrefaei YN, Cancela M,  Castillo E,  Dalton JP,  Tort JF, Brindley PJ (2009) RNA interference targeting leucine aminopeptidase blocks hatching of Schistosoma mansoni eggs. Molecular and Biochemical Parasitology 167, 118-126

Ittiprasert W, Nene R, Miller A, Raghavan N, Lewis F, Hodgson J, Knight M. (2009) Schistosoma mansoni infection of juvenile Biomphalaria glabrata induces a differential stress response between resistant and susceptible snails. Experimental Parasitology 123, 203-211

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Rinaldi G, Morales ME, Cancela M, Castillo E, Brindley PJ, Tort JF (2008) Development of functional genomics tools in trematodes: RNA interference and luciferase reporter gene activity in Fasciola hepatica. PLoS Neglected Tropical Diseases 2(7):e260

Morales ME, Rinaldi G, Gobert GN,  Kines KJ, Tort JF, Brindley PJ (2008) RNA interference of Schistosoma mansoni cathepsin D, the apical enzyme of the hemoglobin proteolysis cascade. Molecular and Biochemical Parasitology, 157 , p. 160-168

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Sripa B, Kaewkes S, Sithithaworn P, Mairiang E, Laha T, Smout M, Pairojkul C, Bhudhisawasdi V, Tesana S, Thinkamrop B, Bethony JM, Loukas A, Brindley PJ (2007) Liver fluke induces cholangiocarcinoma. PLoS Medicine 4(7): e201. PMC1913093

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Knight, M., Miller A., Patterson, C., Rowe, C. Michaels, G., Carr, D., Richards, C., and Lewis, F. 1999. The identification of markers segregating with resistance to Schistosoma mansoni infection in the snail Biomphalaria glabrata. Proceedings of the National Academy of Sciences 96, 1510-1515.

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